CJC-1295 (with DAC)
Summary
CJC-1295 is a synthetic, long-acting analog of growth-hormone-releasing hormone (GHRH) based on GRF(1-29). The "with DAC" version binds serum albumin to extend its half-life to roughly a week, stimulating GH and IGF-1 secretion. A shorter-acting no-DAC form (modified GRF 1-29) also exists. It is a research compound, not an approved medicine.
Quick facts
| Also known as | CJC-1295 DAC, DAC:GRF, modified GRF(1-29) (no-DAC variant) |
| Category | GH secretagogue / GHRH analog |
| Status | Research compound — not an approved drug |
| CAS | 446262-90-4 (with DAC); 863288-34-0 also reported |
| Formula | C165H269N47O46 (with DAC) |
| Molecular weight | ~3647.3 g/mol (with DAC) |
| Sequence | Modified GRF(1-29): Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys + DAC linker |
| Half-life | ~5.8–8.1 days (with DAC; albumin-bound) |
| Storage | Lyophilized: store cold and protected from light. Reconstituted: refrigerate (2–8 °C) and use within a limited window. |
In Plain English
CJC-1295 is a long-lasting lab-made peptide that tells the body to release more of its own growth hormone, and it keeps working for days at a time. Researchers often pair it with other peptides to study a steadier release of growth hormone. It is a research compound, not an approved medicine.
CJC-1295 is a synthetic analog of growth-hormone-releasing hormone (GHRH), engineered for a much longer duration of action than natural GHRH. It is studied for its ability to stimulate the body’s own growth hormone (GH) and IGF-1 release. The name usually refers to the “with DAC” version, which carries a drug-affinity-complex linker; a shorter-acting “no-DAC” form (modified GRF 1-29) also exists. This page is informational only.
How CJC-1295 works
CJC-1295 is built on the first 29 amino acids of GHRH — the active fragment GRF(1-29) — with substitutions that resist enzymatic breakdown. In the “with DAC” version, a maleimide-based drug-affinity-complex (DAC) linker on the C-terminal lysine binds covalently to circulating serum albumin after injection. Because albumin is long-lived in the bloodstream, this dramatically extends the peptide’s half-life and lets it stimulate pulsatile GH and IGF-1 secretion over days rather than minutes.
Reported effects in the research literature
In a published human study, single injections of CJC-1295 produced sustained increases in GH and IGF-1, with an estimated elimination half-life of roughly 5.8 to 8.1 days. Animal work showed that once-daily CJC-1295 could normalize growth in GHRH-deficient mice. Because it acts on the body’s own GHRH pathway, it is frequently discussed alongside GH secretagogues such as ipamorelin.
Clinical development did not continue to wide approval, and long-term safety in humans is not established. CJC-1295 is a research compound, not an approved medicine. The references below link to the primary studies and compound data.
Handling and storage notes
Lyophilized CJC-1295 is generally stored cold and protected from light, then refrigerated once reconstituted and used within a limited window. To convert vial mass and diluent volume into concentration, use the free VialHelp reconstitution calculator, the concentration & volume converter, and the protocol tracker. See the full peptide library for related compounds.
Related compounds and guides
- Ipamorelin — a selective GH secretagogue often discussed with CJC-1295.
- Browse the full peptide library for more GH-related compounds.
- Concentration & volume converter — work out mg, mL and mg/mL.
- How to reconstitute peptides — step-by-step reconstitution method and concentration math.
- Sterile technique — aseptic handling and contamination prevention for research vials.
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References
For informational use only. Not medical advice; consult a qualified healthcare professional. 21+.
CJC-1295 (with DAC) reconstitution calculator
Use the calculator below to find the concentration (mg/mL), draw volume and U-100 syringe units for CJC-1295 (with DAC) once it is reconstituted with bacteriostatic water. CJC-1295 (with DAC) has molecular formula C165H269N47O46 (with DAC) and a molecular weight of ~3647.3 g/mol (with DAC). Enter your vial amount and the water volume to see the lab math — informational use only, not dosing advice.
Open the full calculator · Back to the CJC-1295 (with DAC) profile